Does white matter, grey matter or lesion multi-component relaxation differ between neuromyelitis optica and multiple sclerosis brain?
Elisabeth Baumann 1,2 , Lucy A. E. Matthews 3 , Anthony Traboulsee 1 , Jacqueline Palace 3 , and Shannon Kolind 1
Department of Medicine, University of
British Columbia, Vancouver, BC, Canada,
University Bremen, Bremen, Germany,
University and Oxford Radcliffe Hospitals NHS Trust,
Oxford, United Kingdom
Neuromyelitis optica (NMO) and multiple sclerosis (MS)
are clinically similar demyelinating diseases, however
it has recently been found that each has distinct
pathological characteristics. Illustrating these
differences with MRI has proven challenging. We
investigated the fraction of fast-relaxing signal (fM,
thought to be linked to myelin) and T1 (influenced by
total water content) in NMO, MS and control whole-brain.
fM was decreased in NMO and MS white matter and MS grey
matter. T1 was increased in MS and NMO white matter. No
significant differences were found between diseases, but
MS consistently demonstrated lower fM and higher T1 than
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