Abstract #2061
Is primary progressive multiple sclerosis an independent disease entity? An ultrahigh field MRI lesion analysis
Joseph Kuchling 1 , Ivan Bozin 1 , Jan Drr 1 , Caspar Pfueller 1 , Lutz Harms 2 , Thoralf Niendorf 3 , Friedemann Paul 1 , Tim Sinnecker 1 , and Jens Wuerfel 4
1
NeuroCure Clinical Research Center, Berlin,
Berlin, Germany,
2
Department
of Neurology, Charit Universittsmedizin Berlin,
Berlin, Berlin, Germany,
3
Berlin
Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center
for Molecular Medicine, Berlin, Berlin, Germany,
4
Institute
of Neuroradiology, University Medicine Goettingen,
Goettingen, Germany
Differences between primary progressive (PP) and
relapsing remitting (RR) multiple sclerosis (MS) have
been described, raising the question whether PPMS is
part of the MS disease spectrum or a disease entity of
its own. We addressed this issue by investigating RRMS
and PPMS lesions using UHF-MRI with high spatial
resolution resolution. However, gray and white matter
lesions could not differentiate RRMS and PPMS regarding
plaque morphology, distribution and appearance. Our
findings support the hypothesis that PPMS is part of the
MS disease spectrum and does not represent a disease
entity of its own.
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