Abstract #2064
T2/T1 ratio z-scores as a quantitative metric for Multiple Sclerosis
E Datta 1 , A Zhu 2 , E Crabtree 2 , D Goodin 2 , A Green 2 , S Hauser 2 , B Cree 2 , and RG Henry 1,2
1
Bioengineering, UC San Francisco, San
Francisco, California, United States,
2
Neurology,
UC San Francisco, California, United States
Multiple Sclerosis is a neurodegenerative disease
characterized by lesions resulting from inflammatory
demyelination. The ratio of T2 and T1 brain scans
provides a new metric that can be compared between
controls and patients to observe changes in white matter
integrity that correlate with clinical disability
scores. Z-scores obtained from this comparison show
correlations with T2 lesion volume along with clinical
measures such as EDSS. Thus far, the T2/T1 z-score
metric has shown itself to be a promising substitute for
T2 lesion volume, which does not capture the varying
degrees of disease in sclerotic tissue.
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