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Abstract #2064

T2/T1 ratio z-scores as a quantitative metric for Multiple Sclerosis

E Datta 1 , A Zhu 2 , E Crabtree 2 , D Goodin 2 , A Green 2 , S Hauser 2 , B Cree 2 , and RG Henry 1,2

1 Bioengineering, UC San Francisco, San Francisco, California, United States, 2 Neurology, UC San Francisco, California, United States

Multiple Sclerosis is a neurodegenerative disease characterized by lesions resulting from inflammatory demyelination. The ratio of T2 and T1 brain scans provides a new metric that can be compared between controls and patients to observe changes in white matter integrity that correlate with clinical disability scores. Z-scores obtained from this comparison show correlations with T2 lesion volume along with clinical measures such as EDSS. Thus far, the T2/T1 z-score metric has shown itself to be a promising substitute for T2 lesion volume, which does not capture the varying degrees of disease in sclerotic tissue.

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