Abstract #2065
Neuromyelitis optica spinal cord has increased T1 and decreased myelin water fraction
Clara Tabea Strunk 1,2 , Lucy A.E. Matthews 3 , Anthony Traboulsee 1 , Jacqueline Palace 3 , and Shannon Kolind 1
1
Department of Medicine, University of
British Columbia, Vancouver, BC, Canada,
2
University
of Osnabrck, Osnabrck, Germany,
3
Oxford
University and Oxford Radcliffe Hospitals NHS Trust,
Oxford, United Kingdom
Neuromyelitis optica (NMO) clinically resembles multiple
sclerosis (MS), but has a different mechanism of
demyelination. Brain MRI studies have had difficulty
distinguishing between diseases. Our goal was to
determine whether differences in myelin or total water
content, as measured with multi-component relaxation
imaging, could be detected between NMO and MS in
cervical spinal cord. Surprisingly, little difference
was found between NMO and MS in spinal cord, although
both were significantly altered compared to healthy
controls. Differences in myelin and total water content
were more easily detected between controls and MS or NMO
in spinal cord than in brain.
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