Dynamic Susceptibility Contrast Perfusion Weighted Imaging in Multiple Sclerosis: A Follow-up Study
Sanjeev Chawla 1 , Ilya Kister 2 , Robert I Grossman 1 , and Yulin Ge 1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
New York University Langone Medical Center, New York,
NY, United States
To evaluate changes in perfusion parameters from deep
gray matter regions, 15 patients with multiple sclerosis
(MS) underwent dynamic susceptibility contrast perfusion
weighted imaging (DSC-PWI) twice at an interval of 2
years in a longitudinal study. Using one tailed paired
t-tests, significant elevation in relative cerebral
blood volume (rCBV) and flow (rCBF) were observed from
thalami at follow-up period compared to baseline
probably secondary to inflammatory activities.
Additionally, significant elevation in rCBF and
reduction in relative mean transit time were observed
from basal ganglia. Our preliminary findings suggest
that DSC-PWI may be valuable in detecting follow-up
hemodynamic impairment in MS.
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