Abstract #2074
Multicontrats MRI improved the clinico-radiological correlation in early multiple sclerosis patients with minor deficits
Guillaume Bonnier 1,2 , Alexis Roche 1,3 , David Romanasco 4 , Samanta Simioni 2 , Djalel-Eddine Meskaldji 4 , David Rotzinger 3 , Ying-Chia Lin 5 , Gloria Menegaz 5 , Myriam Schluep 2 , Renaud Du Pasquier 2 , Tilman Johannes Sumpf 6 , Jens Frahm 6 , Jean-Philippe Thiran 4 , Gunnar Krueger 1,7 , and Cristina Granziera 1,2
1
Advanced Clinical Imaging technology group,
Siemens-CIBM, EPFL, Lausanne, Vaud, Switzerland,
2
Department
of Clinical Neurosciences, Centre Hospitalier
Universitaire Vaudois and University of Lausanne,
Lausanne, Vaud, Switzerland,
3
Department
of Radiology, Centre Hospitalier Universitaire Vaudois
and University of Lausanne, Vaud, Switzerland,
4
STI
/ IEL / LTS5, EPFL, Lausanne, Vaud, Switzerland,
5
Dept.
of Computer Science, University of Verona, Itlay, Italy,
6
Biomedizinische
NMR Forschungs GmbH, Max Planck Institute for
Biophysical Chemistry, Gottingen, Germany, Germany,
7
Healthcare
Sector IM&WS S, Siemens Schweiz AG, Suisse, Switzerland
Conventional magnetic resonance imaging (MRI) of
patients with multiple sclerosis provides only limited
insights into the nature of brain tissue damage with
modest clinical-radiological correlations. In this
study, quantitative and semi-quantitative MRI techniques
(T1, T2, T2*, MTR) were applied to study the potential
of the MRI-accessible microstructural information to
predict cognitive and motor scores in patients. A
multiparametric analysis of whole brain abnormalities
showed that MRI measures of microstructural alterations
lead to significant improvement in clinical-radiological
correlations even in the presence of minor functional
deficits.
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