Abstract #2075
Intralesional vein shrinking in multiple sclerosis lacks in severeness -preliminary results from a 7T MRI study
Katharina Mller 1 , Joseph Kuchling 1 , Ivan Bozin 1 , Jan Drr 1 , Caspar Pfueller 1 , Lutz Harms 2 , Thoralf Niendorf 3 , Friedemann Paul 1 , Tim Sinnecker 1,4 , and Jens Wuerfel 1,5
1
Neurocure Research Center, Berlin, Berlin,
Germany,
2
Department
of Neurology, Charit Universittsmedizin Berlin,
Berlin, Berlin, Germany,
3
Berlin
Ultrahigh Field Facility (B.U.F.F), Max Delbrueck Center
for Molecular Medicine, Berlin, Berlin, Germany,
4
Asklepios
Fachklinikum Teupitz, Brandenburg, Germany,
5
Institute
of Neuroradiology, University Medicine Goettingen,
Goettingen, Germany
Vascular alterations in multiple sclerosis (MS) have
been described decades ago. T2* weighted ultrahigh field
MRI at 3 Tesla (T) visualized shrinked brain veins
within MS plaques in vivo. However, this observation may
be influenced by partial volume effects. We addressed
this issue by developing a novel quantification
algorithm and a novel MR-post processing procedure that
generates susceptibility weighted turbo inversion
recovery magnitude (sTIRM) images. We observed less
intralesional venous shrinking on sTIRM compared to T2*
weighted FLASH imaging. Our results confirm initial
reports showing venous shrinking within MS lesions that
is probably not as severe as expected.
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