Abstract #2077
Permeability of the blood-brain barrier predicts conversion from Optic Neuritis to Clinically Definite Multiple Sclerosis
Stig Praestekjaer Cramer 1,2 , Helle Simonsen 1 , Signe Modvig 2 , Jette Lautrup Frederiksen 2 , and Henrik BW Larsson 1
1
FI-Unit, Department of Diagnostics,
University of Copenhagen, Glostrup, Danmark, Denmark,
2
Department
of Neurology, University of Copenhagen, Glostrup,
Danmark, Denmark
We measured permeability of the blood-brain-barrier with
DCE_MRI in 32 patients at onset of Optic Neuritis and 17
matched healthy controls. We found significnatly higher
permeability in normal appearing white matter ON
patients compared to controls, and permeability was
significantly correlated with biomarkers of inflammation
and cell migration in the cerebrospinal fluid. In 50% of
ON cases, the patient will later develop multiple
sclerosis, and we found significant higher permeability
in patients that where diagnosed with MS within one year
after ON onset. These findings further emphasize the
importance of BBB pathology in both ON and MS, and could
be a supplementary prognostic marker for conversion from
ON to MS.
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