Abstract #2078
BBB Breakdown due to Axonal Degeneration: A Potential Confounding Factor for MS Diagnosis
Shu-Wei Sun 1,2 , Christopher Nishioka 3 , Steven Kaspick 4 , Chen-Fang Chung 4 , JoAnn Park 4 , and Hsiao-Fang Liang 4
1
Loma Linda University, Loma Linda, CA,
United States,
2
University
of California, Riverside, Riverside, CA, United States,
3
University
of California, Riverside, CA, United States,
4
Loma
Linda University, CA, United States
Retina ischemia caused axonal degeneration along optic
nerve (ON) and tract (OT) of WldS and wild-type, while
the damage was delayed in WldS. In WldS, ON and OT
showed significant reductions of axial diffusivity in
weeks 1 and 2, respectively, which provided us the time
window of distinguished injure severity between the
proximal (ON) and distal sections (OT) of RGC axons.
Gd-T1WI and Evans blue both showed significant BBB
leakage in RI-affected ON and OT beginning at week 1 in
WldS mice. The remote BBB leakage may be observed in
Gd-T1WI and may confuse the MS diagnosis.
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