Altered cerebrovascular reactivity and its restoration with Interferon beta treatment in multiple sclerosis
Marek Allen 1 , Valentina Tomassini 2 , Nikolaos Petsas 3 , Marco Carni 3 , Emilia Sbardella 3 , Kevin Murphy 1 , Patrizia Pantano 3 , Carlo Pozzilli 3 , and Richard Wise 1
CUBRIC, School of Psychology, Cardiff
University, Cardiff, Cardiff, United Kingdom,
of Medicine, Institute of Psychological Medicine and
Clinical Neurosciences, Cardiff, Cardiff, United
of Neurology and Psychiatry, Sapienza University of
Rome, Rome, Italy
Cerebrovascular reactivity (CVR) is the capacity of
blood vessels to increase blood flow to brain tissue, a
process essential for preserved neurovascular coupling.
Using breath hold-induced hypercapnia we aimed to
investigate CVR in multiple sclerosis patients and the
effect of interferon-beta treatment. We discovered a
reduced reactivity in patients compared with healthy
controls independent of distributed grey matter density
reductions. This was reversed following commencement of
interferon-beta1a treatment to a level comparable with
controls. The effect of immunomodulation on CVR in
patients suggests altered CVR is related to MS
inflammatory activity and could indicate a marker for
early therapeutic effect.
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