Abstract #2081
Thalamic activation during verbal encoding is related to episodic memory in MS
Katherine A Koenig 1 , Ken E Sakaie 1 , Mark J Lowe 1 , Jian Lin 1 , Erik B. Beall 1 , Stephen M Rao 2 , Lael Stone 2 , Robert Bermel 2 , Bruce D Trapp 3 , and Micheal D Phillips 1
1
Imaging Sciences, The Cleveland Clinic,
Cleveland, OH, United States,
2
Neurological
Institute, The Cleveland Clinic, Cleveland, OH, United
States,
3
Neurosciences,
The Cleveland Clinic, Cleveland, OH, United States
We investigate functional activation during the encoding
phase of an episodic memory task in 16 healthy controls
and 32 multiple sclerosis (MS) patients, 16 with intact
cognition and 16 with impaired episodic memory. MS
patients with impaired episodic memory showed lower
thalamic activation during encoding of correct words,
and mean signal in the left thalamus was related to
episodic memory performance and thalamic volume in MS
patients but not controls. A larger sample and
longitudinal measures are required to clarify the
temporal relationship of functional activation, thalamic
atrophy, and cognitive performance in MS.
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