Abstract #2082
Understanding white matter pathology through correlating longitudinal and quantitative MRI metrics weekly in the cuprizone mouse model of demyelination
Vanessa L Palmer 1,2 , Sheryl L Herrera 3 , Jonathan D Thiessen 4 , Shenghua Zhu 5 , Richard Buist 4 , Xin-Mi Li 6 , and Melanie Martin 2,7
1
Biomedical Engineering, University of
Manitoba, Winnipeg, Manitoba, Canada,
2
Physics,
University of Winnipeg, Winnipeg, Manitoba, Canada,
3
Physics
and Astronomy, University of Manitoba, Winnipeg,
Manitoba, Canada,
4
Radiology,
University of Manitoba, Winnipeg, Manitoba, Canada,
5
Pharmacology
and Therapeutics, University of Manitoba, Winnipeg,
Manitoba, Canada,
6
Psychiatry,
University of Alberta, Edmonton, Alberta, Canada,
7
Biomedical
Engineering, Physics & Astronomy, Radiology,
Pharmacology & Therapeutics, University of Manitoba,
Winnipeg, Manitoba, Canada
DTI, qMTI, and multicomponent T
2
relaxometry
might help quantify changes related to demyelination. To
understand the interplay different MRI methods have as
white matter changes in the corpus callosum of the
cuprizone mouse model,
in
vivo
T
2
-weighted
(T2w) and MTI were acquired weekly in control and
cuprizone-fed mice. Weekly DTI, qMTI, T
1
/T
2
relaxometry,
T2w imaging, and EM were used to analyze
ex
vivo
tissue
after each week of cuprizone delivery. The addition of
the weekly
ex
vivo
tissue
analysis allows for a more complete understanding of the
correlations between MR metrics and EM measures of
tissue pathology.
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