Abstract #2083
Determinants and Consequences of Brain Atrophy, Disability, Demyelination, Remyelination and Neuronal Loss in an MS Model
Istvan Pirko 1 , Jeffrey Gamez 1 , Pascal Alihnuii Atanga 1 , Stephanie J LaFrance 2 , Slobodan I Macura 3 , and Aaron J Johnson 2
1
Department of Neurology, Mayo Clinic,
Rochester, MN, United States,
2
Department
of Immunology, Mayo Clinic, Rochester, MN, United
States,
3
NMR
Core Facility, Mayo Clinic, Rochester, MN, United States
Brain atrophy in MS is an important determinant of
functional outcome, yet its pathogenesis remains
unclear. Using a virally induced murine MS model, we
determined that class I haplotype plays a major
influence on atrophy development. Atrophy and disability
are independent from each other in mouse strains that
dont develop persistent demyelination; however, atrophy
and disability strongly correlate when chronic
demyelination is present. Brain atrophy development is
overall unrelated to and independent of demyelination,
and is the consequence of axonal/neuronal loss.
Remyelination results in axonal preservation, preserved
disability, and lack of brain atrophy development in the
studied model.
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