Abstract #2084
Differences in the Brain of Irradiated Mice Investigated with White Matter Imaging Techniques
A. Elizabeth de Guzman 1,2 , Jonathan Bishop 1 , Jacob Ellegood 1 , and Brian J, Nieman 1,2
1
Mouse Imaging Centre, Hospital for Sick
Children, Toronto, Ontario, Canada,
2
Department
of Medical Biophysics, University of Toronto, Toronto,
Ontario, Canada
Magnetization transfer (MT), susceptibility weighted
(SW) and diffusion tensor (DT) MR imaging are commonly
used techniques to study white matter damage in
neurodegenerative diseases. Using these methods, we
investigated the effects of cranial irradiation on white
matter pathology in the mouse. Differences were
detectable in many white matter structures using MT and
SW, but not DT MRI. We hypothesize that dymelination
plays a larger role in irradiation induced damage than
axonal changes. In the future we will study the effect
of myelin protection in this irradiation model, and see
how this affects the imaging outcomes.
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