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Abstract #2084

Differences in the Brain of Irradiated Mice Investigated with White Matter Imaging Techniques

A. Elizabeth de Guzman 1,2 , Jonathan Bishop 1 , Jacob Ellegood 1 , and Brian J, Nieman 1,2

1 Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, 2 Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Magnetization transfer (MT), susceptibility weighted (SW) and diffusion tensor (DT) MR imaging are commonly used techniques to study white matter damage in neurodegenerative diseases. Using these methods, we investigated the effects of cranial irradiation on white matter pathology in the mouse. Differences were detectable in many white matter structures using MT and SW, but not DT MRI. We hypothesize that dymelination plays a larger role in irradiation induced damage than axonal changes. In the future we will study the effect of myelin protection in this irradiation model, and see how this affects the imaging outcomes.

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