Abstract #2087
Histological correlation of manganese enhanced MRI in the demyelinating disease model brain.
Masaki Fukunaga 1,2 , Makoto Masumura 3 , Shuichi Koda 3 , Tomokazu Shimonaga 3 , Ryuichi Nakamura 3 , Yuki Mori 1 , and Yoshichika Yoshioka 1,2
1
Biofunctional Imaging, IFReC, Osaka
University, Suita, Osaka, Japan,
2
Brain
Functional Imaging Technologies, CiNet, NICT-Osaka
University, Suita, Osaka, Japan,
3
Asubio
Pharma Co. Ltd., Kobe, Hyogo, Japan
Cuprizone is a mitochondrial toxin that induces
apoptosis of oligodendrocytes and demyelination in the
central nervous system, and is used for animal model of
de- and re-myelination in multiple sclerosis. Recently,
manganese enhanced MRI (MEMRI) is utilized to reveal the
mechanisms of neuroinflammatory and neurodegenerative
disorders, especially it enhances image contrast of the
glial (astrocytes and microglia) activations in the
pathological conditions. In this study, we investigated
manganese contrast enhancement in cuprizone induced
demyelinated mouse brain using 11.7T ultra high field
MRI, and analyzed with histology and glial marker
expressions.
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