Abstract #2088
Multiexponential T 2 and Quantitative Magnetization Transfer in Rodent Brain Models of Hypomyelination
Kathryn L West 1 , Nathaniel D Kelm 1 , Daniel F Gochberg 2 , Robert P Carson 3 , Kevin C Ess 3 , and Mark D Does 1,4
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Radiology
and Radiological Sciences, Vanderbilt University, TN,
United States,
3
Neurology,
Vanderbilt University, TN, United States,
4
Vanderbilt.University
Institute of Imaging Science, Vanderbilt University, TN,
United States
Myelin water imaging (MWI) by multi-exponential
transverse relaxation (MET
2
) and quantitative
Magnetization Transfer (qMT) provide valuable
information about myelin content and microstructure in
white matter, yet have a known discord between measures.
3D high resolution imaging protocols allow for efficient
whole brain evaluation of abnormal myelination in
recently developed hypomyelinated mouse models. In
addition, comparing MWF and PSR measures to histology
can provide insight to better understand white matter
microstructure.
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