Abstract #2089
Pre-symptomatic Degeneration and Dysmyelination of Axons in a Huntingtons Mouse Model Revealed by Diffusion Tensor MRI
Allen Q. Ye 1 , Rodolfo Gatto 1,2 , Ehsan Tavassoli 2 , M. Andrea Buenaventura 2 , Gerardo A. Morfini 2 , and Richard L. Magin 1
1
Department of Bioengineering, University of
Illinois at Chicago, Chicago, IL, United States,
2
Department
of Anatomy and Cell Biology, University of Illinois at
Chicago, Chicago, IL, United States
The cause of Huntingtons disease (HD) is well defined;
however, the molecular mechanisms underlying these
deficits remain unknown. In this abstract, we explore
the use diffusion tensor imaging of double transgenic
YFP-R6/2 mouse, which allows the direct visualization of
HD through intrinsic fluorescent properties, in
pre-symptomatic mice. Both diffusion tensor imaging and
quantitative immunofluorescence studies showed
differential degeneration of axonal fibers across the
corpus callosum (CC) long before the development of
HD-like motor symptoms.
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