Diffusion tensor imaging detects demyelination and axonal injury in mouse spinal cord
Nabeela Nathoo 1 , Dayae Jeong 2 , Michael B. Keough 3 , Tad Foniok 1 , V. Wee Yong 3 , and Jeff F. Dunn 1,4
Radiology, University of Calgary, Calgary,
University, Houston, Texas, United States,
Neurosciences, University of Calgary, Calgary, Alberta,
Imaging Centre, University of Calgary, Calgary, Alberta,
We used a focal demyelinating model in mouse spinal
cord, with a known course of demyelination and
remyelination, to assess if scalar measures obtained
using diffusion tensor imaging (DTI) could detect
demyelination. During the time point with maximal
demyelination, radial diffusivity and mean diffusivity
were elevated while fractional anisotropy was reduced.
Anterior to the lesion, axial diffusivity was
significantly reduced at the time point of maximal
demyelination compared to the time point with ongoing
remyelination, suggestive of axonal injury. Taken
together, these results support the use of DTI to assess
demyelination and axonal injury in spinal cord.
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