Abstract #2098
Age-dependent decrease of capillary density in arcAbeta mouse model of cerebral amyloidosis detected with relaxation rate shift index Q mapping at 9.4T using a cryoprobe
Giovanna Diletta Ielacqua 1 , Felix Schlegel 1 , Markus Rudin 2 , and Jan Klohs 1
1
Institute for Biomedical Engineering, ETH,
Zurich, Zurich, Switzerland,
2
Institute
for Biomedical Engineering, Institute of Pharmacology
and Toxicology, Zurich, Switzerland
It has been shown that in Alzheimers Disease amyloid
deposition in cerebral microvessels plays an important
role in cerebral perfusion. In this MRI study we
investigated capillary density through relaxation rate
shift index Q, and perfusion with bolus tracking . All
measurements were performed on a 9.4T scanner equipped
with a cryogenic phased-array coil, recording a 2D Spin
Echo-RARE, a 3D Gradient Echo-FLASH and an EPI sequence.
Our results show there is a decrease of capillary
density and cortical perfusion in 24months-old arcA
mice, suggesting that the index Q is a reliable
indicator of capillary density in brain
microvasculopathies
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
