Abstract #2099
Neurofunctional and neurochemical endophenotypes in mouse models of autism spectrum disorder investigated by fMRI and MRS
Marija M. Petrinovic 1,2 , Michael Saxe 1 , Barbara Biemans 1 , Peter Scheiffele 2 , Markus von Kienlin 1 , and Basil Knnecke 1
1
F. Hoffmann-La Roche Ltd, Pharma Research &
Early Development, DTA Neuroscience, Basel, Basel,
Switzerland,
2
Biocenter,
University of Basel, Basel, Basel, Switzerland
Alterations in neural function and neurochemistry have
been proposed as mechanisms underlying behavioural
deficits associated with autism spectrum disorder (ASD).
We have leveraged fMRI/MRS in five mouse models of ASD
to bridge the gap between genetic/molecular findings and
behavioural phenotypes. fMRI revealed prominent
neurofunctional alterations in brain regions implicated
in socio-emotional, cognitive and sensorimotor
processing. fMRI fingerprints were heterogeneous across
the models, yet, they reflect the complexity of ASD
symptoms found in patients. 1H-MRS in these models
showed consistent changes in cerebral glutamate levels
indicative of a dysbalance in excitatory/inhibitory
neurotransmission which has been purported as a
substrate for ASD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
