Abstract #2106
Ex Vivo MR microscopic imaging identifies multiple neuroanatomical correlates of functional motor deficits in a rat model of bilirubin encephalopathy
Martin Herbert Schaffhauser 1,2 , Dominik Maria Reisinger 1,2 , Joel Marx 1 , Michael Porambo 1 , Jiangyang Zhang 3 , Michael V Johnston 1 , and Seyed Ali Fatemi 1,2
1
Neuroscience, Hugo W. Moser Research
Institute at Kennedy Krieger, Baltimore, MD, United
States,
2
Neurology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States,
3
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
MD, United States
Despite the preventable nature of bilirubin
encephalopathy, cases continue to occur and remain a
significant problem in newborns. The Gunn rat is a rat
model, featuring an enzyme deficiency resembling Crigler
Najjar syndrome. Sulfadimethoxine was used to exaggerate
bilirubin encephalopathy, leading to a dystonic
phenotype. We evaluated the model in the chronic phase
ex vivo through acquiring high-resolution images of
T2-weighted sequences as well as DTI. While there were
no FA changes, we show decreased cerebellar volumes in
all mutant rats as well as decreased GP, ICP and MCP
volumes in the dystonic animals.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
