A pathophysiological wiring defect in epileptic animals as depicted by DTI fiber tracking

The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) is a well-validated model of absence epilepsy, and dopamine has been shown to play a modulatory role on absence seizures. The fasciculus retroflexus (FR) is a white matter tract involved in the release of dopamine. A microscopic 3D-Diffusion Tensor Imaging sequence was developed on 7T Bruker MRI and applied ex vivo on GAERS and Non Epileptic Control (NEC) rats. DTI fiber-tracking showed a decrease in the number of fibers detected in the FR, suggesting a contribution of this tract in the modified dopaminergic tone observed in epileptic rats.

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