Abstract #2110
Erythropoietin improves cerebral malaria outcome in mice by attenuating brain edema and enhancing perfusion
Raman Saggu 1 , Emilie Pecchi 1 , Guillaume Duhamel 1 , Dorothe Faille 2 , Frdric Frassineti 3 , Laurent Daniel 3 , Georges Grau 4 , Monique Bernard 1 , Patrick J Cozzone 1 , and Angele VIOLA 1
1
Aix-Marseille Universit-CRMBM UMR CNRS
7339, Marseille, France,
2
Laboratoire
d'Hmatologie et d'Immunologie Biologiques - U698,
Paris, France,
3
Service
dAnatomie Pathologique, Hpital la Timone, Marseille,
France,
4
The
University of Sydney, Camperdown, Australia
Cerebral malaria (CM) is the most lethal complication in
the course of Plasmodium infection. Our purpose was to
decipher the mechanisms by which EPO ameliorates CM in
mice. We used an approach combining MRI techniques at
high field (conventional MRI, perfusion MRI with the
pCASL technique and angiography) for in vivo cerebral
studies, with immunological and histological techniques.
Our results show that administration of EPO prevents
brain edema in responding animals, which is the cause of
death in sham-treated CM mice. Our results demonstrate
that EPO enhance brain perfusion via both short-term
non-erythropoietic effects of EPO, and long-term
erythropoietic effects.
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