Dorzolamide Restores Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma
Saurav B Chandra 1 , Eric R Muir 1 , and Timothy Q Duong 1
Research Imaging Institute, University of
Texas Health Science Center San Antonio, San Antonio,
TX, United States
Dorzolamide (DZ) is clinically used to treat glaucoma by
reducing intraocular pressure. However, its effect on
blood flow is unknown. The goal of this study is to
investigate the effect of topical DZ application on
retinal and choroidal blood flow in DBA/2J mice, an
established mouse model of glaucoma. Results are
compared with C57BL/6J mice, used as a control group.
This study indicates increased blood flow in the choroid
of both DBA/2J as well as C57BL/6J mice models following
topical application of Dorzolamide.
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