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Abstract #2115

MRI colonic stress test for differentiating different subtypes of constipation

Gemma Chaddock 1 , Ching Lam 2 , Klara Garsed 2 , Caroline Hoad 1 , Carolyn Costigan 1 , Susan Pritchard 1 , Luca Marciani 2 , Robin Spiller 2 , and Penny Gowland 1

1 Physics & Astronomy, The University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 NIHR Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals Trust, Nottingham, Nottinghamshire, United Kingdom

We have assessed the colonic response of patients with chronic constipation (CC) to a laxative, using novel MRI methods. 40 patients took part in this one day open label study where serial MRI was used to assess whole gut transit time, small bowel water content, colonic volumes and colonic motility following oral ingestion of 1 L of a macrogol based laxative. We found quantifiable differences between the colonic responses of patients with different types of CC following ingestion of the laxative. This presents the opportunity to differentiate between patients with different forms of CC, allowing for more personalised treatment.

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