Abstract #2116
Preliminary investigations of colonic motility from Cine MRI; use of registration techniques for quantitative analysis
Caroline L. Hoad 1 , Valentin Hamy 2 , Klara Garsed 3 , Luca Marciani 3 , Robin C. Spiller 3 , Stuart A. Taylor 2 , David Atkinson 2 , Penny A. Gowland 1 , and Alex Menys 2
1
Sir Peter Mansfield Magnetic Resonance
Centre, University of Nottingham, Nottingham,
Nottinghamshire, United Kingdom,
2
Centre
for Medical Imaging, Division of Medicine, UCL, London,
United Kingdom,
3
Nottingham
Digestive Disease Centre, Biomedical Research Unit in GI
and Liver Diseases, University Hospitals NHS Trust and
University of Nottingham, Nottingham, Nottinghamshire,
United Kingdom
This study describes a preliminary investigation of the
use of registration techniques to assess colonic
motility. Cine MRI data from 10 healthy subjects pre-
and 1 hour post an oral dose of a common laxative
underwent dual registration to remove breathing effects
and parameterise bowel motion. Significant area changes
from 3 regions of interest across the AC were converted
into a motility index and compared to observer scores of
bowel wall contractions. The greatest agreement between
the motility index and observer scores were seen for a
change in area of greater than 5% of mean area.
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