Abstract #2133
Accuracy of liver fat quantification by CT, MRI and US: a prospective comparison with Magnetic Resonance Spectroscopy (MRS)
Harald Kramer 1,2 , Mark A Kliewer 2 , Perry J Pickhardt 2 , Diego Hernando 2 , Gunag-Hong Chen 2 , and Scott B Reeder 2,3
1
Department of Radiology, Ludwig-Maximilians-University
Munich, Munich, Germany,
2
Department
of Radiology, University of Wisconsin - Madison,
Madison, Wisconsin, United States,
3
Department
of Medical Physics, University of Wisconsin - Madison,
Madison, Wisconsin, United States
Accumulation of triglycerides in hepatocytes is the
hallmark feature of non-alcoholic fatty liver disease
and can lead to inflammation, fibrosis and cirrhosis.
Since the accepted diagnostic standard (biopsy) is
invasive and suffers from poor sampling variability,
there is a need for a comprehensive, accurate and
non-invasive quantitative biomarker. We evaluated a
proton density fat-fraction chemical-shift based MRI
technique, dual-energy CT and US shear-wave velocity in
comparison to MR spectroscopy. PDFF-MRI shows excellent
correlation with MRS whereas CT Hounsfield-Units and CT
fat decomposition showed good and moderate correlation,
respectively. US SW did not demonstrate any correlation
with MRS.
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