Abstract #2136
Quantitative comparison of hepatic fat fraction in type 2 diabetes with triple-echo gradient echo MRI and proton MRS
Sunil K. Valaparla 1,2 , Goldie R. E. Boone 1 , Feng Gao 1 , Timothy Q. Duong 1,2 , and Geoffrey D. Clarke 1,2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States,
2
Radiology,
University of Texas Health Science Center at San
Antonio, San Antonio, Texas, United States
Type 2 diabetes (T2DM) has been associated with
excessive fat accumulation in the liver and definitive
diagnosis using non-invasive fat estimation methods is
essential for early treatment. We measured the liver fat
fraction in T2DM subjects using triple-echo GRE MRI and
compared with current gold standard 1H-MRS. BlandAltman
plots and regression analysis between methods exhibited
excellent concordance and correlation. Triple-echo GRE
MRI is fast, accurate, provides excellent concordance
and correlation with MRS and can be used to replace
time-consuming MRS for longitudinal and large cohort
studies.
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