Evaluation of Hepatic Fat Fraction Measured by MRI and Plasma Lipoprotein Levels in High-Fat Diet Fed Non-Human Primate

We have established non-human primate (NHP) models of dyslipidemia by chronic feeding (9 mo.) two high-fat diets to male cynomolgus monkeys. Compared to normal diet fed NHPs, on average these animals (n=28) have doubled their total cholesterol, HDL- and LDL-cholesterol, but maintained triglyceride at baseline level. Additionally, their MRI-derived hepatic fat fraction (FF) increased from 2.4 0.6% to 7.7 4.5%. However, individual FFs do not correlate well with lipoprotein levels or ratios, probably due to small sample size and narrow data range. Our findings provide insights into lipid metabolism dysfunction in the dyslipidemic model and its potential utility for translational research.

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