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Abstract #2155

Distinction between non-advanced and advanced liver fibrosis: Comparison between MR DCE imaging and T2-corrected IVIM at 3.0T.

Benjamin LEPORQ 1 , Frank Pilleul 2,3 , Jerome Dumortier 4 , Olivier Guillaud 4 , Thibaud Lefort 5 , Pierre-Jean Valette 5 , and Olivier Beuf 2

1 Center for research on inflammation, Universit PARIS 7 ; INSERM U1149, Paris, France, 2 CREATIS CNRS UMR 5220; INSERM U1044; INSA Lyon; UCBL Lyon 1, Universite de Lyon, Villeurbanne, France, 3 Centre de lutte contre le cancer, Centre Lon Berard, Lyon, France, 4 CHU Edouard Herriot; Department of hepatology, Hospices Civils de Lyon, Lyon, France, 5 CHU Edouard Herriot; Department of gastro-intestinal imaging, Hospices Civils de Lyon, Lyon, France

Our objective was to evaluate T2-corrected IVIM and perfusion imaging using a MR-DCE technique for the distinction between non-advanced and advanced fibrosis in patients with chronic liver diseases. The link between perfusion-related diffusion given by IVIM and quantitative perfusion parameters given by MR-DCE imaging was investigated. Results indicated that the combination of IVIM and MR-DCE imaging do not bring additional information for fibrosis assessment in a large spectra of etiologies. Indeed, perfusion parameters given by MR-DCE imaging alone are relevant to evaluate fibrosis severity. Strong correlation between portal perfusion and perfusion related diffusion coefficient illustrated that IVIM reflects the hemodynamic changes occurring in fibrous damage. Pure molecular diffusion coefficient was affected by the deposition of extracellular matrix components and by fat vesicle suggesting that fat overload can constitute a confounding factor in fibrosis assessment with IVIM. Nevertheless, if fat overload is addressed, IVIM could be a useful injection-free method to distinguish between non-advanced and advanced fibrosis.

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