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Abstract #2156

Imaging Liver Fibrosis and Response to Rapamycin Therapy

Christian T. Farrar 1 , Bryan C. Fuchs 2 , Helen Day 1 , Nicholas Rotile 1 , Danielle DePeralta 2 , Arun Subramaniam 3 , Kenneth K. Tanabe 2 , and Peter Caravan 1

1 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2 Surgical Oncology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 3 Sanofi-Aventis, Bridgewater, NJ, United States

There is a critical unmet medical need for non-invasive methods for quantifying liver fibrosis to facilitate early diagnosis, monitor disease progression, and assess response to therapies. Here we demonstrate the use of the collagen-targeted contrast agent EP-3533 to monitor progression of liver fibrosis in a bile duct ligation rat model of liver fibrosis and to assess response to rapamycin therapy.

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