Abstract #2159
A study on T1 mapping of Healthy and Fibrotic Human Liver
Anup Singh 1 , Damodar Reddy 1 , Mohammad Haris 1,2 , Kejia Cai 1,3 , Rebecca Wells 4 , Emma E. Furth 5 , K. Rajender Reddy 4 , Hari Hariharan 1 , and Ravinder Reddy 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Research
Branch, Sidra Medical and Research Center, Doha, Qatar,
3
Radiology,
University of Illinois at Chicago, Chicago, IL, United
States,
4
Department
of Medicine, University of Pennsylvania, Philadelpha,
PA, United States,
5
Department
of Pathology and Laboratory Medicine, University of
Pennsylvania, Philadelpha, PA, United States
Objective of current study was to evaluate T1 changes
in fibrotic human liver. In the current study, T1
mapping and analysis of healthy (n=10) and fibrotic
(n=10) livers of human subjects on 1.5T clinical scanner
were carried out. T1 values were significantly higher
in fibrotic livers compared to healthy livers. In
addition, T1 maps of some of the fibrotic liver were
more heterogeneous compared to healthy liver. Histogram
analysis of T1 values was also performed. Results from
this preliminary study show the potential of staging
liver fibrosis based upon increased T1 values in
combination with width of histogram and mode values.
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