Relative Signal Loss from Fat Using In- and Out-of-phase Images for Indicating Renal Health

A recent study in diabetic mice suggests a correlation between renal cortical fat content and severity of renal disease. We retrospectively evaluated the fat content of kidneys in 14 human subjects with varying degrees of renal failure ranging from normal renal function to dialysis dependence, based on in- and out-of-phase T1-weighted axial images of the kidneys. Correlation between fat content measured with the in-phase/out-of-phase images and the body mass index (BMI) or estimated glomerular filtration rate (eGFR) was investigated. We find no significant correlation between renal fat content and severity of renal disease in humans with diabetic nephropathy.

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