Abstract #2188
Arterial Spin Labeling and Diffusion Tensor Imaging of Early Kidney Changes in Pediatric Sickle Cell Disease Patients
Shannon Donnola 1 , Lan Lu 1,2 , Jane Little 3 , Katherine Dell 4 , Connie Piccone 5 , and Chris Flask 1,6
1
Radiology, Case Western Reserve University,
Cleveland, Ohio, United States,
2
Urology,
Case Western Reserve University, Cleveland, Ohio, United
States,
3
Hematology
and Oncology, University Hosptials-Case Medical Center,
Cleveland, Ohio, United States,
4
Pediatrics,
Cleveland Clinic Lerner College of Medicine, Cleveland,
Ohio, United States,
5
Pediatrics, University
Hospitals-Case Medical Center, Cleveland, Ohio, United
States,
6
Biomedical
Engineering, Case Western Reserve University, Cleveland,
Ohio, United States
Chronic kidney disease (CKD) is an important
complication in sickle cell disease and begins in
childhood. Unfortunately, current clinical measures of
kidney function are insensitive to early kidney changes,
a time point when therapies could be more effective. In
this initial study, we used Arterial Spin Labeling and
Diffusion Tensor Imaging techniques to assess kidney
changes in pediatric SCD patients in comparison to
healthy control subjects. Cortical Apparent Diffusion
Coefficients (ADC), medullary Fractional Anisotropy
(FA), and cortical perfusion were all significantly
reduced in young SCD patients. These quantitative MRI
techniques could potentially compliment current clinical
assessments of kidney function.
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