Abstract #2199
Evaluation of the temporal variation of diffusion and micro-perfusion in cisplatin induced rodent renal fibrosis models using multi-b diffusion weighted MR imaging
Haoran Sun 1 , Huanhuan Wu 1 , and Ziheng Zhang 2
1
Radiology, Tianjin Medical University
Hospital, Tianjin, Tianjin, China,
2
MR
Research China, GE Healthcare, Shanghai, Shanghai, China
Intravoxel incoherent motion (IVIM) DWI has recently
shown potential to assess functional changes of renal
fibrosis. From the findings through multi-b DW-MRI
measurements on cisplatin induced rodent renal fibrosis
models, the temporal variation of ADC values behaved as
a weight of the true diffusion and pseudo-diffusion. The
biomarkers resulted from mono-exponential model
exhibited a dual phase temporal variation, while those
from bi-exponential model remained a single tendency of
variation. According to the histopathological
observation that the worsening of renal fibrosis with
time, the bi-exponential model might be a better choice
for an accurate indication of the evolution of renal
fibrosis.
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