Imaging Glomeruli in a Clinical MRI System at 3 T
Jorge Chacn-Caldera 1 , Philipp Krmer 1 , Sebastian Domsch 1 , Stefania Geraci 2 , Norbert Gretz 2 , and Lothar R Schad 1
Computer Assisted Clinical Medicine,
Heidelberg University, Mannheim, Germany,
Research Center, Heidelberg University, Mannheim,
The number of glomeruli in kidneys is associated with
kidney diseases. There is interest to discover if
glomerular quantification in humans is possible.
Currently, glomerular imaging with MRI is achieved using
in vitro samples in preclinical systems with main
magnetic fields of minimum 7T. This work presents the
first ever glomerular images acquired with a clinical
scanner at 3T. We used two cationazed-ferritin labeled
rat kidneys and a Siemens Magnetom to demonstrate that
currently available clinical scanners are capable of
performing glomerular imaging. The parameters were also
used to assess the current standpoint towards future
human kidney measurements.
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