Abstract #2201
Quantitative Assessment of Renal T2* Heterogeneity with Minkowski Functionals for the Detection of Ischemia/Reperfusion Injury
Andreas Pohlmann 1 , Jan Hentschel 1 , Karen Arakelyan 1 , Mandy Fechner 2 , Uwe Hoff 2 , Gordana Bubalo 2 , Kathleen Cantow 3 , Sonia Waiczies 1 , Duska Dragun 2 , Bert Flemming 3 , Erdmann Seeliger 3 , and Thoralf Niendorf 1
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Moleculare Medicine, Berlin,
Germany,
2
Nephrology
and Intensive Care Medicine, Campus Virchow-Klinikum and
Center for Cardiovascular Research,
Charite-Universitaetsmedizin Berlin, Berlin, Germany,
3
Institute
of Physiology and Center for Cardiovascular Research,
Charit Medical Faculty, Berlin, Germany
Imbalance between renal tissue oxygen demand and supply
is a pivotal element in the pathophysiologic cascade of
ischema/reperfusion injury. Parametric mapping of renal
T2*, which is known to be blood oxygenation level
dependent, to monitor I/R in rats if feasible, however,
comparison of absolute renal T2* is barely feasible,
because absolute values depend on magnetic field
strength, B0 homogeneity, etc. By applying image
heterogeneity analysis by 2D Minkowski functionals to
renal T2* data we investigated whether renal T2*
heterogeneity analysis allows a differentiation between
healthy nave kidneys, ischemic kidneys, and kidneys
during subsequent reperfusion.
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