Contrast/SNR optimization for the Imaging of Cationized-Ferritin labeled Glomeruli at 9.4T

Imaging whole kidney volumes to visualize glomeruli with MRI requires long acquisition times. Wrong parameters selection can reduce or even impede the visualization of the glomeruil. In this work we present quick measurements of effective transverse relaxation time (T2*) in the kidney cortex and cationized-ferritin labeled glomeruli at 9.4T in mouse kidneys. The contrast between them was also calculated for the whole range of measured echo times. These measurements can be easily extrapolated and/or replicated in other systems and field strengths to facilitate the glomerular imaging, reduce the scanning times and improve the accuracy and efficiency of possible glomerular quantifications.

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