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Abstract #2203

Non-invasively Quantitative Measurements of Intrarenal Oxygen Extraction Fraction (OEF) in Rabbits with Unilateral Renal Artery Stenosis Using MRI

Xiaodong Zhang 1 , Yue Mi 2 , Jing Wang 3 , Jingyun Wu 1 , Kai Zhao 1 , Jian Luo 1 , Xuedong Yang 1 , Xiaoying Wang 1,4 , Jue Zhang 4 , and Hongyu An 5

1 Department of Radiology, Peking University First Hospital, Beijing, Beijing, China, 2 Department of Urology, Peking University First Hospital, Beijing, Beijing, China, 3 School of physics, Peking University, Beijing, Beijing, China, 4 Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, Beijing, China, 5 Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Quantitative measurement of renal oxygenation is of central importance in understanding and treating renal diseases and oxygen extraction fraction (OEF) can provide a valid criterion for evaluation the tissue oxygen metabolism under both normal and disease states. According to the Yablonskiy and Haackes biophysical analytical model, the intra-renal OEF can be estimated using a multi-echo gradient and spin echo (MEGSE) sequence. In this study, we will demonstrate the ability to obtain quantitative estimates of intra-renal OEF noninvasively in normal and unilateral renal artery stenosis rabbits of the Multi-Echo Gradient and Spin Echo (MEGSE).

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