Abstract #2212
Multiparametric functional MRI for assessment of acute renal allograft rejection in mice correlation with renal histology and the composition of T-cell infiltrates
Katja Hueper 1,2 , Song Rong 3 , Marcel Gutberlet 1,2 , Matti Peperhove 1 , Susanne Tewes 1 , Amelie Barrmeyer 1 , Martin Meier 4 , Sibylle von Vietinghoff 3 , Michael Mengel 5 , Hermann Haller 3 , Frank Wacker 1,2 , Dagmar Hartung 1,2 , and Faikah Gueler 3
1
Radiology, Hannover Medical School,
Hannover, Germany,
2
REBIRTH
Cluster of Excellence, Hannover Medical School,
Hannover, Germany,
3
Nephrology,
Hannover Medical School, Hannover, Germany,
4
Institute
of Animal Science, Hannover Medical School, Hannover,
Germany,
5
Alberta
Transplant Applied Genomics Centre, University of
Alberta, Edmonton, Alberta, Canada
We investigated whether multiparametric functional MRI
allows evaluation of renal allograft rejection in mice.
An acute rejection was induced by allogenic kidney
transplantation; animals after isogenic transplantation
were used as controls. Three weeks after transplantation
renal perfusion (ASL), T1-/ T2-relaxation times and
ADC-values were determined using a 7T-scanner. Animals
after allogenic transplantation developed an acute
T-cell-mediated rejection. In these animals, renal
perfusion impairment was stronger, T1- and T2-values
were higher and ADC was lower compared to animals after
isogenic transplantation. Functional MRI-parameters
significantly correlated with the extent of
T-cell-infiltrates. Thus, functional MRI may improve
non-invasive diagnosis of renal allograft rejection.
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