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Abstract #2213

MicroMR Imaging of Renal Interstitial Fibrosis in a Unilateral Ureteric Obstruction Model

Septian Hartono 1,2 , Tong San Koh 1 , In Chin Song 3 , Lin Zheng 3 , Wing Sum Lee 3 , Laurent Martarello 4 , and Choon Hua Thng 1

1 National Cancer Centre Singapore, Singapore, Singapore, Singapore, 2 Nanyang Technological University, Singapore, Singapore, Singapore, 3 SingHealth Experimental Medicine Centre, Singapore, Singapore, 4 Roche Translational Medicine Hub, Singapore, Singapore

We aim to determine if DCE-MRI and DWI can detect renal interstitial fibrosis in mice. Renal fibrosis is induced by unilateral ureteric obstruction (UUO) with survival surgery. Six mice were scanned before the UUO procedure dan one week after the UUO. Renal fibrosis is quantified by amount of fibrosis as measured by Sirius Red stain. There is a drop of ADC as derived from DWI and renal parenchymal mean transit time (PMTT) as derived from DCE-MRI in the cortices of the ligated kidneys. PMTT correlated significantly with % of Sirius Red, signifying potentials of using DCE-MRI as biomarker of renal fibrosis.

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