Meeting Banner
Abstract #2214

Quantification of Iron Oxide Nanoparticles in a large animal model using MRI

Oliviero L Gobbo 1 , Andrew J Fagan 2 , Colin Ryan 3 , Deirdre Edge 4 , Christine Shortt 4 , Marek Radomski 3 , Adriele Prina-Mello 5 , Farouk Markos 4 , and Yuri Volkov 5

1 School of Pharmacy and Pharmaceutical Sciences and TCIN, Trinity College Dublin, Dublin, Leinster, Ireland, 2 Centre for Advanced Medical Imaging (CAMI), St Jamess Hospital / Trinity College Dublin, Dublin, Ireland, 3 School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland, 4 Physiology Department, University College Cork, Cork, Ireland, 5 School of Medicine, Trinity College Dublin, Dublin, Ireland

MULTIFUN consortium's current goal is to develop and validate multifunctional SPION for the early detection and treatment of breast and pancreatic cancer while reducing side effects for patients compared to conventional treatment with anti-cancer drugs. This joint therapeutic and diagnostic property has been called theranostic. Our study establishes an MRI protocol for the quantification of SPIONs in ex-vivo pig organs (i.e. kidneys) which can potentially be used in preclinical cancer research and in translational medicine.

This abstract and the presentation materials are available to members only; a login is required.

Join Here