Abstract #2225
1H MRS as a Biomarker for Placental Insufficiency in the Growth Restricted Fetus
Gillian Macnaught 1 , Scott Semple 1,2 , Calum Gray 1,3 , Mary Simpson 4 , Jane Norman 4 , Jane Walker 5 , and Fiona Denison 4
1
Clinical Research Imaging Centre, University
of Edinburgh, Edinburgh, Scotland, United Kingdom,
2
Centre
for Cardiovascular Sciences, University of Edinburgh,
Edinburgh, Scotland, United Kingdom,
3
Wellcome
Trust Clinical Research Facility, University of
Edinburgh, Edinburgh, Scotland, United Kingdom,
4
Tommy's
Centre for Maternal and Fetal Health, University of
Edinburgh MRC Centre for Reproductive Health, Edinburgh,
Scotland, United Kingdom,
5
Simpson
Centre for Reproductive Health, Edinburgh Royal
Infirmary, Edinburgh, Scotland, United Kingdom
Placental insufficiency commonly leads to Fetal Growth
Restriction (FGR) and stillbirth. The current
recommendation is to deliver the baby prematurely which
is not without risk. We present proton placenta spectra
acquired in-utero of 4 FGR and 4 normal pregnancies,
acquired on a 3T Siemens Verio MR system using the PRESS
technique. Spectra were analysed using JMRUI. The ratios
of glutamine and glutamate (Glx) to choline (cho) in the
placentas of 4 FGR pregnancies were lower than in their
gestation-matched controls. This may provide an in vivo
marker of placental function in these difficult to
manage cases.
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