Abstract #2231
Modulation of the abdominal visceral and subcutaneous adipose tissue by fat storage-inducing transmembrane (FIT) proteins - An Imaging Study
Jadegoud Yaligar 1 , Diego A Miranda 2 , Bhanu Prakash KN 1 , David Lawrence Silver 2 , and S Sendhil Velan 1
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore, Singapore,
2
Signature
Research Program in Cardiovascular & Metabolic Diseases,
Duke-NUS Graduate Medical School Singapore, Singapore,
Singapore
Fat deposition in the body can be regulated by silencing
the fat storage-inducing transmembrane (FIT) protein in
in vivo animal models. In our current study we have
evaluated the abdominal fat in both FIT2
adipose-specific knockout (AF2KO) and their littermate
(LL) control mouse model using MRI technique. Volumes of
SAT and VAT fat fractions were significantly (p < 0.05)
higher in LL control compared to AF2KO mice. Both SAT
and VAT fat contents of AF2KO mice were significantly (p
< 0.05) lower than LL mice, indicating a vital role of
FIT2 in lipid accumulation. Silencing the FIT2 protein
has reduced the fat accumulation even in high fat diet
fed conditions. Modulation (either down regulation or
silencing) of these proteins by drugs in obesity and
type 2 diabetic conditions might be helpful in
preventing the fat accumulation in the body.
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