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Abstract #2231

Modulation of the abdominal visceral and subcutaneous adipose tissue by fat storage-inducing transmembrane (FIT) proteins - An Imaging Study

Jadegoud Yaligar 1 , Diego A Miranda 2 , Bhanu Prakash KN 1 , David Lawrence Silver 2 , and S Sendhil Velan 1

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore, Singapore, 2 Signature Research Program in Cardiovascular & Metabolic Diseases, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore

Fat deposition in the body can be regulated by silencing the fat storage-inducing transmembrane (FIT) protein in in vivo animal models. In our current study we have evaluated the abdominal fat in both FIT2 adipose-specific knockout (AF2KO) and their littermate (LL) control mouse model using MRI technique. Volumes of SAT and VAT fat fractions were significantly (p < 0.05) higher in LL control compared to AF2KO mice. Both SAT and VAT fat contents of AF2KO mice were significantly (p < 0.05) lower than LL mice, indicating a vital role of FIT2 in lipid accumulation. Silencing the FIT2 protein has reduced the fat accumulation even in high fat diet fed conditions. Modulation (either down regulation or silencing) of these proteins by drugs in obesity and type 2 diabetic conditions might be helpful in preventing the fat accumulation in the body.

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