Abstract #2232
Serum Metabolic Signature in an animal model of binge eating by Nuclear Magnetic Resonance Spectroscopy
Valeria Righi 1 , Silvia Alboni 2 , Luisa Schenetti 2 , Carlo Cifani 3 , Nicoletta Brunello 2 , and Adele Mucci 4
1
Department for the Quality of Life Studies,
University of Bologna, Rimini, RN, Italy,
2
Department
of Life Sciences, University of Modena and Reggio
Emilia, Modena, MO, Italy,
3
School of
Pharmacy, Pharmacology Unit, University of Camerino,
Camerino, MC, Italy,
4
Department
of Chemical and Geological Sciences, University of
Modena and Reggio Emilia, Modena, MO, Italy
Binge Eating (BE) episodes are characterized by
uncontrollable, distressing eating of a large amount of
highly palatable food (HPF). Considerable evidence
suggests that BE may be caused by a unique interaction
between dieting and stress. In our model BE for HPF is
evoked in rats by the combination of cyclic food
restrictions and stress. In order to investigate BE
behavior in female rats, for the first time, we analyzed
the metabolic profile obtained from biological fluids of
rats exposed or not to cycles of food restriction and a
stressful challenge through the High Resolution Nuclear
Magnetic Resonance Spectroscopy.
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