Abstract #2233
Effect of High Fat/High Fructose Diet on Canine Model Using Quantitative Fat Water MRI
Myriam Diaz Martinez 1,2 , Aliya Diaz Gifford 2,3 , Philip E Williams 4 , Alan D Diaz Cherrington 4 , Malcolm J Avisom 5 , and E Brian Welch 3,6
1
Department of Radiology and Radiological
Sciences, Vanderbilt University, School of Medicine,
Nashville, TN, United States,
2
Chemical
and Physical Biology Program, Vanderbilt University
Medical Center, Nashville, TN, United States,
3
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University Medical Center, Nashville, TN, United States,
4
Department
of Molecular Physiology and Biophysics, Vanderbilt
University, Nashville, TN, United States,
5
Department
of Pharmacology, Vanderbilt University, School of
Medicine, Nashville, TN, United States,
6
Department
of Radiology and Radiological Sciences, Vanderbilt
University, School of Medicine, Nasville, TN, United
States
The purpose of this study was to detect organ-specific
changes in fat-water signal over the course of high
fat/high fructose diet consumption. The effect of the
diet was evaluated exposing a canine animal model to the
diet and measurements were acquired using the
quantitative method of fat-water MRI (FWMRI), with
interleaved multiecho pulse sequence. This technique is
a promising new imaging modality for the research areas
of obesity and metabolic diseases. Results indicate that
liver and subcutaneous tissues fat fraction increased
over the course of the study, consistent with the
development of obesity comorbidities such as type 2
Diabetes Mellitus.
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