Abstract #2234
USPIO enhanced MRI in NAFLD; a feasibility and proof of concept study
Loek P. Smits 1 , Bram Coolen 2 , Wouter Nijhof 1 , Jurgen H. Runge 2 , Erik S. Stroes 1 , and Aart J. Nederveen 2
1
Department of Vascular Medicine, AMC,
Amsterdam, Netherlands,
2
Department
of Radiology, AMC, Amsterdam, Netherlands
Differentiation between simple steatosis and
steatohepatitis (NASH) is of clinical and prognostic
importance, but no non-invasive diagnostic tests
currently available are capable of this. Previous
studies showed the promise of iron-oxide particle
enhanced MRI as a diagnostic tool to identify patients
with NASH. In the present study we present a protocol
for ultrasmall particles of iron-oxide (USPIO) enhanced
MRI, and demonstrate that patients with NASH have a
decreased hepatic uptake of USPIOs. Future studies are
needed to show whether USPIO-MRI indeed is capable of
differentiation NASH from simple steatosis.
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