The effect of ROI size and analysis technique on IVIM parameters in the liver
Alexander D Cohen 1 , Mark D Hohenwalter 2 , and Kathleen M Schmainda 2
Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States,
Medical College of Wisconsin, Milwaukee, WI, United
The intravoxel incoherent motion (IVIM) analysis
technique has been used to model diffusion in the liver.
Perfusion-related components can be extracted from the
DWI signal through the collection of multiple b-values.
Once the data is collected, there are a number of
different ways to analyze that data. IVIM parameter
values were compared with different ROIs and analysis
techniques in order to determine which combination
provided the best separation between normal and
cirrhotic livers. Differences were found for different
ROI sizes. Larger ROIs provided better separation
between normal and cirrhotic livers, and voxelwise
extraction techniques were less variable than ROI
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