Abstract #2254
The effect of very low b-values on the IVIM-derived pseudodiffusion parameter in the liver
Alexander D Cohen 1 , Moira C Schieke 2 , Mark D Hohenwalter 2 , and Kathleen M Schmainda 2
1
Biophysics, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Radiology,
Medical College of Wisconsin, Milwaukee, WI, United
States
The intravoxel incoherent motion (IVIM) analysis
technique has been used to model diffusion in the liver.
This model allows for the extraction of
perfusion-related components from the DWI signal. When
b<50 s/mm
2
are
not included in the b-value distribution, the
pseudodiffusion parameter has tended to be lower than
when b<50 s/mm
2
are
included. This study used simulations to examine the
effect of very low b-values on the pseudodiffusion
parameter. Pseudodiffusion tended to be underestimated
when very low b-values were excluded from the
distribution. It is recommended to include at least two
very low b-values when performing IVIM studies in the
liver.
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