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Abstract #2254

The effect of very low b-values on the IVIM-derived pseudodiffusion parameter in the liver

Alexander D Cohen 1 , Moira C Schieke 2 , Mark D Hohenwalter 2 , and Kathleen M Schmainda 2

1 Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States

The intravoxel incoherent motion (IVIM) analysis technique has been used to model diffusion in the liver. This model allows for the extraction of perfusion-related components from the DWI signal. When b<50 s/mm 2 are not included in the b-value distribution, the pseudodiffusion parameter has tended to be lower than when b<50 s/mm 2 are included. This study used simulations to examine the effect of very low b-values on the pseudodiffusion parameter. Pseudodiffusion tended to be underestimated when very low b-values were excluded from the distribution. It is recommended to include at least two very low b-values when performing IVIM studies in the liver.

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