Abstract #2257
Semi-Continuous Regularized Multi-Exponential Fitting Model for Diffusion Weighted Imaging of the Liver
Burkhard Mdler 1,2 and Jrgen Gieseke 2,3
1
Neurosurgery, University of Freiburg,
Freiburg, Germany,
2
Philips
Healthcare, Hamburg, Germany,
3
Radiology,
University of Bonn, Bonn, Germany
Several studies have utilized IVIM for various clinical
applications in the abdomen. We tested performance and
validity of a novel semi-continuous multi-exponential
PFG-diffusion signal analysis for the detection and
quantification of vascular perfusion in the liver with a
patient friendly free-breathing approach. Classical
chi-squared multi-exponential fitting algorithms are
susceptible to fail without sufficient SNR. We show that
regularized NNLS-techniques together with high number of
b-value DWI-acqusition have better performance on the
estimates of IVIM parameters and might encourage new
attempts of clinical IVIM-based methods in general.
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